Role of mean platelet volume in pregnancy to predict gestational diabetes mellitus in the first trimester.

Autor: Colak E; Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Konya, Turkey., Ozcimen EE; Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Konya, Turkey., Ceran MU; Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Konya, Turkey., Tohma YA; Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Ankara, Turkey., Kulaksızoglu S; Department of Biochemistry, Medical Faculty, Baskent University, Konya, Turkey.
Jazyk: angličtina
Zdroj: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2020 Nov; Vol. 33 (21), pp. 3689-3694. Date of Electronic Publication: 2019 Apr 04.
DOI: 10.1080/14767058.2019.1583730
Abstrakt: Objectives: Gestational diabetes mellitus (GDM) is defined as glucose intolerance detected for the first time in pregnancy or identified during pregnancy. Mean platelet volume (MPV) is a marker of activation and function of platelet. Several studies investigated the relation between MPV and GDM. The purpose of the present study is to predict GDM in the first trimester by using MPV value. Materials and methods: Two hundred pregnant women with GDM and 200 normal pregnant women were enrolled in the study. The first trimester MPV values of GDM and control groups were compared to predict GDM in the first trimester. Results: Women with GDM had higher MPV value compared with the control group ( p  < .001). The area under the receiver-operator curve was 0.70 for MPV. The cutoff value of MPV was 7.38 fl with 70% sensitivity and 60% specificity. According to the ages, MPV value was higher in GDM group in the individuals who were above 28-year-old ( p  < .001). Conclusion: MPV can be used to predict GDM in the first trimester.
Databáze: MEDLINE
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