| Autor: |
Patterson T; 1 Division of Cardiovascular The Rayne Institute BHF Centre of Research Excellence King's College London St. Thomas' Hospital London United Kingdom., McConkey HZR; 1 Division of Cardiovascular The Rayne Institute BHF Centre of Research Excellence King's College London St. Thomas' Hospital London United Kingdom., Ahmed-Jushuf F; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom., Moschonas K; 3 Department of Cardiology King's College Hospital NHS Foundation Trust London United Kingdom., Nguyen H; 1 Division of Cardiovascular The Rayne Institute BHF Centre of Research Excellence King's College London St. Thomas' Hospital London United Kingdom., Karamasis GV; 4 Department of Cardiology Essex Cardiothoracic Centre Basildon United Kingdom., Perera D; 1 Division of Cardiovascular The Rayne Institute BHF Centre of Research Excellence King's College London St. Thomas' Hospital London United Kingdom., Clapp BR; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom., Roxburgh J; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom., Blauth C; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom., Young CP; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom., Redwood SR; 1 Division of Cardiovascular The Rayne Institute BHF Centre of Research Excellence King's College London St. Thomas' Hospital London United Kingdom., Pavlidis AN; 2 Department of Cardiothoracic Guy's and St Thomas' NHS Foundation Trust London United Kingdom. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2019 Apr 16; Vol. 8 (8), pp. e011279. |
| DOI: |
10.1161/JAHA.118.011279 |
| Abstrakt: |
Background The Heart Team ( HT ) comprises integrated interdisciplinary decision making. Current guidelines assign a Class Ic recommendation for an HT approach to complex coronary artery disease ( CAD ). However, there remains a paucity of data in regard to hard clinical end points. The aim was to determine characteristics and outcomes in patients with complex CAD following HT discussion. Methods and Results This observational study was conducted at St Thomas' Hospital (London, UK). Case mixture included unprotected left main, 2-vessel (including proximal left anterior descending artery) CAD , 3-vessel CAD , or anatomical and/or clinical equipoise. HT strategy was defined as optimal medical therapy ( OMT ) alone, OMT +percutaneous coronary intervention ( PCI ), or OMT +coronary artery bypass grafting. From April 2012 to 2013, 51 HT meetings were held and 398 cases were discussed. Patients tended to have multivessel CAD (74.1%), high SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) scores (median, 30; interquartile range, 23-39), and average age 69±11 years. Multinomial logistic regression analysis performed to determine variables associated with HT strategy demonstrated decreased likelihood of undergoing PCI compared with OMT in older patients with chronic kidney disease and peripheral vascular disease. The odds of undergoing coronary artery bypass grafting compared with OMT decreased in the presence of cardiogenic shock and left ventricular dysfunction and increased in younger patients with 3-vessel CAD . Three-year survival was 60.8% (84 of 137) in the OMT cohort, 84.3% (107 of 127) in the OMT + PCI cohort, and 90.2% in the OMT +coronary artery bypass grafting cohort (92 of 102). Conclusions In our experience, the HT approach involved a careful selection process resulting in appropriate patient-specific decision making and good long-term outcomes in patients with complex CAD . |
| Databáze: |
MEDLINE |
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