Streptococcus pneumoniae - An Uncommon but Noteworthy Cause of Intrauterine Fetal Demise and Acute Necrotizing Funisitis.

Autor: Ouseph MM; a Department of Pathology and Laboratory Medicine, Rhode Island Hospital , Providence , RI , USA.; b Warren Alpert Medical School of Brown University , Providence , RI , USA., Krigman H; c Department of Pathology & Immunology, Washington University School of Medicine , St. Louis , MO , USA., He M; b Warren Alpert Medical School of Brown University , Providence , RI , USA.; c Department of Pathology & Immunology, Washington University School of Medicine , St. Louis , MO , USA.; d Department of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island , Providence , RI , USA.
Jazyk: angličtina
Zdroj: Fetal and pediatric pathology [Fetal Pediatr Pathol] 2019 Aug; Vol. 38 (4), pp. 352-358. Date of Electronic Publication: 2019 Apr 03.
DOI: 10.1080/15513815.2019.1587121
Abstrakt: Background : Streptococcus pneumoniae ( S . pneumoniae ) is an uncommon cause of amniotic fluid infection and intrauterine fetal demise. Case report : A 39-year-old G8P2052 presented with preterm premature rupture of membrane at 22 weeks gestation and had a spontaneous vaginal delivery of a neonate who soon expired. Placental examination revealed retroplacental hematoma, acute necrotizing chorioamnionitis, acute three-vessel vasculitis and necrotizing funisitis of the umbilical cord. Postmortem examination demonstrated features of amniotic fluid infection syndrome with blood culture growing S. pneumoniae. Antenatal screening does not typically quantify S . pneumoniae infection, but small series have found vaginal colonization in fewer than 1% of women. Intrauterine or peritoneal infection derives primarily from ascending infection although other routes are hypothetically possible. Intra-amniotic and neonatal infections by S. pneumoniae are associated with high morbidity and mortality. Conclusion : S. pneumoniae should be considered in perinatal death of immature fetus with severe amniotic fluid infection syndrome and acute necrotizing funisitis.
Databáze: MEDLINE
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