Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

Autor: Sharma A; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Buschmann MM; The University of Chicago Medicine, Chicago, Illinois, USA., Gilbert JA; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Jazyk: angličtina
Zdroj: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Aug; Vol. 106 (2), pp. 317-328. Date of Electronic Publication: 2019 May 07.
DOI: 10.1002/cpt.1437
Abstrakt: The human body, with 3.0 × 10 13 cells and more than 3.8 × 10 13 microorganisms, has nearly a one-to-one ratio of resident microbes to human cells. Initiatives like the Human Microbiome Project, American Gut, and Flemish Gut have identified associations between microbial taxa and human health. The study of interactions between microbiome and pharmaceutical agents, i.e., pharmacomicrobiomics, has revealed an instrumental role of the microbiome in modulating drug response that alters the therapeutic outcomes. In this review, we present our current comprehension of the relationship of the microbiome, host biology, and pharmaceutical agents such as cardiovascular drugs, analgesics, and chemotherapeutic agents to human disease and treatment outcomes. We also discuss the significance of studying diet-gene-drug interactions and further address the key challenges associated with pharmacomicrobiomics. Finally, we examine proposed models employing systems biology for the application of pharmacomicrobiomics and other -omics data, and provide approaches to elucidate microbiome-drug interactions to improve future translation to personalized medicine.
(© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics.)
Databáze: MEDLINE
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