Urothelial carcinoma of the upper urinary tract: preoperative pyuria is not correlated with bladder cancer recurrence and survival.

Autor: Milojevic B; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia. em2bogomir@yahoo.com.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia. em2bogomir@yahoo.com., Dzamic Z; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Bojanic N; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Durutovic O; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Janicic A; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Kajmakovic B; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Milojevic IG; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia., Bumbasirevic U; Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Grubor N; Clinic for Digestive Surgery, Clinical Center of Serbia, Belgrade, Serbia., Grujicic SS; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2019 May; Vol. 51 (5), pp. 831-838. Date of Electronic Publication: 2019 Apr 01.
DOI: 10.1007/s11255-019-02133-1
Abstrakt: Objective: To identify the impact of preoperative pyuria on the bladder cancer recurrence and survival of patients who were treated surgically for UTUC.
Patients and Methods: Study included 319 consecutive patients who were treated with RNU for UTUC. Cox proportional hazard regression models were used to evaluate the association of preoperative pyuria with outcome.
Results: Eighty patients (25.1%) had pyuria. Preoperative pyuria was associated with sex (P = 0.01), tumor focality (P = 0.01), tumor size (P = 0.05), tumor stage (P = 0.01), lymph node metastasis (P = 0.01), lymphovascular invasion (P = 0.02), and chemotherapy (P = 0.04). A total of 102 patients recurred, with a median time to bladder recurrence of 24.2 months. Bladder cancer recurrence-free survival rates for these 319 patients at 1, 3, 5, 7, and 10 years were 84.6, 72.4, 69.0, 68.3, and 68.0%, respectively. Preoperative pyuria was not independently associated with bladder cancer recurrence (HR 1.15; p = 0.5). Preoperative pyuria was associated with OS (HR 1.57; p = 0.02) and CSS (HR 1.65; p = 0.02). However, preoperative pyuria was not independently associated with OS and CSS (HR 1.07; p = 0.79).
Conclusions: Preoperative pyuria is unable to predict outcomes in a single-centre series of consecutive patients who were treated with RNU.
Databáze: MEDLINE
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