Risk factors for longitudinal changes in left ventricular diastolic function among women and men.

Autor:	Rueda-Ochoa OL; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Basic Sciences, Universidad Industrial de Santander, Bucaramanga, Colombia., Smiderle-Gelain MA; Department of Cardiology, Federal University of Health Sciences UFCSPA, Porto Alegre, Porto Alegre, Brazil., Rizopoulos D; Department of Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands., Dhana K; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., van den Berge JK; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Echeverria LE; Heart Failure and Heart Transplant Clinic, Fundacion Cardiovascular de Colombia, Floridablanca, Colombia., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Deckers JW; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Franco OH; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2019 Sep; Vol. 105 (18), pp. 1414-1422. Date of Electronic Publication: 2019 Apr 01.
DOI:	10.1136/heartjnl-2018-314487
Abstrakt:	Objective: To evaluate changes in left ventricular diastolic function (LVDF) parameters and their associated risk factors over a period of 11 years among community-dwelling women and men. Methods: Echocardiography was performed three times among 870 women and 630 men (age 67±3 years) from the prospective population-based Rotterdam Study during a period of 11-year follow-up. Changes in six continuous LVDF parameters were correlated with cardiovascular risk factors using a linear-mixed effect model (LMM). Results: In women, smoking was associated with deleterious longitudinal changes in deceleration time (DT) (Beta (β): 7.73; 95% CI 2.56 to 12.9) and high-density lipoprotein cholesterol was associated with improvement of septal e' (β: 0.37; 95% CI 0.13 to 0.62) and E/e' ratio (β: -0.46; 95% CI -0.84 to -0.08) trajectories. Among men, diabetes was associated with deleterious longitudinal changes in A wave (β: 3.83; 95% CI 0.06 to 7.60), septal e' (β: -0.40; 95% CI -0.70 to -0.09) and E/e' ratio (β: 0.60; 95% CI 0.14 to 1.06) and body mass index was associated with deleterious longitudinal changes in A wave (β: 1.25; 95% CI 0.84 to 1.66), E/A ratio (β: -0.007; 95% CI -0.01 to -0.003), DT (β: 0.86; 95% CI 0.017 to 1.71) and E/e' ratio (β: 0.12; 95% CI 0.06 to 0.19). Conclusions: Smoking among women and metabolic factors (diabetes mellitus and body mass index) among men showed larger deleterious associations with longitudinal changes in LVDF parameters. The favourable association of HDL was mainly observed among women. This study, for the first time, evaluates risk factors associated with changes over time in continuous LVDF parameters among women and men and generates new hypothesis for further medical research. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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