Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis.

Autor: Kamel KM; Pharmacology Department, National Organization for Drug Control and Research, Egypt. Electronic address: doctorkamelmohamed@gmail.com., Gad AM; Pharmacology Department, National Organization for Drug Control and Research, Egypt., Mansour SM; Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Egypt; Pharmacology, Toxicology & Biochemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Egypt., Safar MM; Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Egypt; Pharmacology & Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Egypt., Fawzy HM; Pharmacology Department, National Organization for Drug Control and Research, Egypt.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2019 Jun 01; Vol. 226, pp. 68-76. Date of Electronic Publication: 2019 Mar 28.
DOI: 10.1016/j.lfs.2019.03.063
Abstrakt: Aims: Rheumatoid arthritis is usually accompanied by various comorbidities especially on the psychological side such as depression. This study aimed at revealing the potential curative effects of venlafaxine (VFX), a serotonin/norepinephrine reuptake inhibitor (SNRI), on experimentally-induced arthritis in rats.
Methods: Arthritis was induced by injecting complete Freund's adjuvant (CFA, 0.1 ml, s.c.). One day thereafter, VFX (50 mg/kg, p.o.) was given for 21 days. Methotrexate was used as a standard disease modifying anti-rheumatic drug.
Key Findings: CFA injection caused prominent arthritis evident by the increase in the hind paw and ankle diameter accompanied by elevating tumor necrosis factor-alpha, interleukin-6, interleukin-17 and matrix metalloproteinase-3 levels, effects that were diminished by VFX. Moreover, VFX down regulated gene expressions of receptor activator of nuclear factor kappa-B (NF-кB) ligand and signal transducer and activator of transcription-3 beside hampering immunohistochemical expression of vascular endothelial growth factor and NF-кB. This SNRI also improved the oxidant status of the hind limb as compared to the arthritic group. Nonetheless, MTX was better in amendment of arthritis authenticated by its effect on some inflammatory and oxidative stress biomarkers.
Significance: This study provides a novel therapeutic use of VFX as a considerable anti-arthritic drug and offers an incentive to expand its use in RA.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: