The influence of acute hyperglycaemia on brachial artery flow-mediated dilatation in the early and late follicular phases of the menstrual cycle.
Autor: | Williams JS; Cardiovascular Stress Response Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada., Stimpson TV; Cardiovascular Stress Response Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada., Tremblay JC; Cardiovascular Stress Response Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada., Fenuta AM; Human Vascular Control Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada., Pyke KE; Cardiovascular Stress Response Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. |
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Jazyk: | angličtina |
Zdroj: | Experimental physiology [Exp Physiol] 2019 Jun; Vol. 104 (6), pp. 957-966. Date of Electronic Publication: 2019 Apr 22. |
DOI: | 10.1113/EP087536 |
Abstrakt: | New Findings: What is the central question of the study? This is the first study to examine the impact of acute hyperglycaemia on endothelial function [flow-mediated dilatation (FMD)] in premenopausal women across the early and late follicular (EF and LF) phases of the menstrual cycle. What is the main finding and its importance? Flow-mediated dilatation was impaired 90 min after glucose ingestion, with no significant difference between phases. This indicates that women are susceptible to acute hyperglycaemia-induced endothelial dysfunction in both the EF and LF phases of the menstrual cycle, despite potentially vasoprotective elevations in estradiol levels during the LF phase. Abstract: Acute hyperglycaemia transiently impairs endothelial function in healthy men when assessed via flow-mediated dilatation (FMD). However, research in female participants is lacking, and the impact of menstrual phase [early follicular (EF) and late follicular (LF)] on vulnerability to acute hyperglycaemia-induced endothelial dysfunction is unknown. Seventeen healthy, naturally menstruating women [21 ± 1 years old (mean ± SD)] participated in three visits. During two visits (EF (© 2019 The Authors. Experimental Physiology © 2019 The Physiological Society.) |
Databáze: | MEDLINE |
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