Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Autor: Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. amy.bentley@nih.gov., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lim E; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Deng X; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Liu J; Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lu Y; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Centre for Quantitative Medicine, Academic Medicine Research Institute, Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Huffman JE; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Li C; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Richard MA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Noordam R; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Baker J; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Aschard H; Centre de Bioinformatique, Biostatistique, et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Biostatistics, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Ding J; Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Manning AK; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Alver M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Divers J; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hagemeijer Y; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Hartwig FP; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK., He M; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Hsu FC; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Hung YJ; Endocrinology and Metabolism, Tri-Service General Hospital, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Komulainen P; Foundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Leander K; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Lin KH; Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan., Luan J; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, Finland., Matoba N; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Nolte IM; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands., Pietzner M; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Prins B; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Riaz M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Robino A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Said MA; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA., Scott RA; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Sofer T; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Stancáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA., van der Most PJ; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden., Wang TD; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.; National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Wang Y; Department of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Xiang YB; SKLORG and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhang W; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Zhao JH; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Adeyemo A; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Afaq S; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Amini M; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arzumanyan Z; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Ballantyne C; Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.; Houston Methodist Debakey Heart and Vascular Center, Houston, TX, USA., Barr RG; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Broeckel U; Section of Genomic Pediatrics, Departments of Pediatrics, Medicine, and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Brown M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Charumathi S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Centre for Quantitative Medicine, Academic Medicine Research Institute, Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Christensen K; Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark., Concas MP; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Connell JM; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., de Las Fuentes L; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Doumatey A; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Duan Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eaton CB; Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USA., Eppinga RN; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Forouhi NG; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Forrester T; UWI Solutions for Developing Countries, University of the West Indies, Kingston, Jamaica., Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel., Gandin I; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gharib SA; Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA., Gigante B; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA., Heikkinen S; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Hirata M; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Minato-ku, Japan., Hixson JE; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands., Jia Y; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Joehanes R; Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., Johnson C; Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, China., Justice AE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Koh WP; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Kolcic I; Department of Public Health, Department of Medicine, University of Split, Split, Croatia., Kooperberg C; Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Lakka TA; Foundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Langefeld CD; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Langenberg C; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA., Lehne B; Institute of Clinical Sciences, Department of Molecular Sciences, Imperial College, London, UK., Lewis CE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Liang J; Department of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Lin S; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Liu K; Epidemiology, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Loh M; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Lohman KK; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., Luzzi A; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Manichaikul AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., McKenzie CA; Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, Jamaica., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Technische Universität München, Munich, Germany., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Murray AD; Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Nalls MA; Data Tecnica International, Glen Echo, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Nauck M; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Papanicolau GJ; Epidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Peters A; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Epidemiology, Faculty of Medicine, Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig Maximilian University, Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Polasek O; Department of Public Health, Department of Medicine, University of Split, Split, Croatia.; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia.; Gen-info, Ltd, Zagreb, Croatia., Poulter N; School of Public Health, Imperial College, London, UK., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Reiner AP; Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.; Department of Biobank Research, Umeå University, Umeå, Sweden., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Robinson JG; Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA, USA., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Rosendaal FR; Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Schmidt CO; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Schreiner PJ; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Scott WR; Institute of Clinical Sciences, Department of Molecular Sciences, Imperial College, London, UK.; National Heart and Lung Institute, Imperial College, London, UK., Sever P; National Heart and Lung Institute, Imperial College, London, UK., Shi Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Snieder H; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Strauch K; Genetic Epidemiology, Faculty of Medicine, Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig Maximilian University, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tang H; Department of Genetics, Stanford University, Stanford, CA, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tiemeier H; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., van Heemst D; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wang H; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Wang L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Williams CA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wilson G Sr; Jackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Young K; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yu C; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, PA, USA., Zhou J; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA., Becker DM; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, UK., Cooper RS; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA., de Faire U; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Psychology, University of Edinburgh, Edinburgh, UK., Elliott P; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Broad Institute of MIT and Harvard, Boston, MA, USA., Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Freedman BI; Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College, London, UK., Gasparini P; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Horta BL; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Juang JJ; National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kammerer CM; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Kooner JS; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; National Heart and Lung Institute, Imperial College, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Lee IT; Endocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, Finland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Oldehinkel AJ; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Rauramaa R; Foundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Scott J; National Heart and Lung Institute, Imperial College, London, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands., Wagenknecht LE; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Wang JS; Endocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, China., Wareham NJ; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wu T; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zeggini E; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Evans MK; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Liu Y; Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Mook-Kanamori DO; Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Kelly TN; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Fox ER; Cardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Zhu X; Department of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Bierut LJ; Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Gauderman WJ; Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. rotimic@mail.nih.gov., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA. adrienne@bu.edu.
Jazyk: angličtina
Zdroj: Nature genetics [Nat Genet] 2019 Apr; Vol. 51 (4), pp. 636-648. Date of Electronic Publication: 2019 Mar 29.
DOI: 10.1038/s41588-019-0378-y
Abstrakt: The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Databáze: MEDLINE