Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.
Autor: | Rubis B; Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA., Luczak MW; Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA., Krawic C; Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA., Zhitkovich A; Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA. Electronic address: anatoly_zhitkovich@brown.edu. |
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Jazyk: | angličtina |
Zdroj: | Free radical biology & medicine [Free Radic Biol Med] 2019 May 20; Vol. 136, pp. 12-21. Date of Electronic Publication: 2019 Mar 26. |
DOI: | 10.1016/j.freeradbiomed.2019.03.026 |
Abstrakt: | Bleomycin is a redox-active drug with anticancer and other clinical applications. It is also frequently used as a tool in fundamental research on cellular responses to DNA double-strand breaks (DSBs). A conversion of bleomycin into its DNA-breaking form requires Fe, one-electron donors and O (Copyright © 2019 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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