Lower prevalence of non-cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility.

Autor:	Huang H; Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut., Kuang H; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China., Sun F; Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut., Diamond MP; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia., Legro RS; Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania., Coutifaris C; Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania., Alvero R; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado., Robinson RD; Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas., Casson PR; Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont., Christman GM; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan., Hansen KR; University of Oklahoma College of Medicine, Oklahoma City, Oklahoma., Santoro N; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado., Eisenberg E; Fertility and Infertility Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland., Zhang H; Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut. Electronic address: heping.zhang@yale.edu.
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 2019 May; Vol. 111 (5), pp. 1011-1019.e1. Date of Electronic Publication: 2019 Mar 27.
DOI:	10.1016/j.fertnstert.2019.01.020
Abstrakt:	Objective: To study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). Design: A secondary analysis of data from three randomized clinical trials. Setting: Academic health centers. Patient(s): A total of 2,249 patients with normal uterine cavities. Interventions(s): None. Main Outcome Measure(s): The presence or absence of non-cavity-distorting fibroids. Result(s): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non-cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non-cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. Conclusion(s): A lower prevalence of non-cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI. (Copyright © 2019 American Society for Reproductive Medicine. All rights reserved.)
Databáze:	MEDLINE
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