A Strategy toward Icetexane Natural Products.

Autor: Moon DJ; Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19176, United States., Al-Amin M; Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19176, United States., Lewis RS; Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19176, United States., Arnold KM; Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health Service, Newark, DE 19713, United States.; Department of Medical Laboratory Sciences, University of Delaware, Newark, DE 19176, United States., Yap GPA; Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19176, United States., Sims-Mourtada J; Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health Service, Newark, DE 19713, United States.; Department of Medical Laboratory Sciences, University of Delaware, Newark, DE 19176, United States.; Department of Biological Sciences, University of Delaware, Newark, DE 19176, United States., Chain WJ; Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19176, United States.
Jazyk: angličtina
Zdroj: European journal of organic chemistry [European J Org Chem] 2018 Jul 06; Vol. 2018 (25), pp. 3348-3351. Date of Electronic Publication: 2018 May 16.
DOI: 10.1002/ejoc.201800707
Abstrakt: Icetexane diterpenoids are richly complex polycyclic natural products that have been described with a variety of biological activities. We report here a general synthetic approach toward the 6-7-6 tricyclic core structure of these interesting synthetic targets based on a two-step enolate alkylation and ring-closing metathesis reaction sequence.
Databáze: MEDLINE
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