Molecular architecture of the zebra finch arcopallium.

Autor: Mello CV; Department of Behavioral Neuroscience, OHSU, Portland, Oregon., Kaser T; Department of Behavioral Neuroscience, OHSU, Portland, Oregon., Buckner AA; Department of Behavioral Neuroscience, OHSU, Portland, Oregon., Wirthlin M; Department of Behavioral Neuroscience, OHSU, Portland, Oregon., Lovell PV; Department of Behavioral Neuroscience, OHSU, Portland, Oregon.
Jazyk: angličtina
Zdroj: The Journal of comparative neurology [J Comp Neurol] 2019 Oct 15; Vol. 527 (15), pp. 2512-2556. Date of Electronic Publication: 2019 May 02.
DOI: 10.1002/cne.24688
Abstrakt: The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Here we present a molecular characterization of the arcopallium in the zebra finch, a passerine songbird species and a major model organism for vocal learning studies. Based on in situ hybridization for arcopallial-expressed transcripts (AQP1, C1QL3, CBLN2, CNTN4, CYP19A1, ESR1/2, FEZF2, MGP, NECAB2, PCP4, PVALB, SCN3B, SCUBE1, ZBTB20, and others) in comparison with cytoarchitectonic features, we have defined 20 distinct regions that can be grouped into six major domains (anterior, posterior, dorsal, ventral, medial, and intermediate arcopallium, respectively; AA, AP, AD, AV, AM, and AI). The data also help to establish the arcopallium as primarily pallial, support a unique topography of the arcopallium in passerines, highlight similarities between the vocal robust nucleus of the arcopallium (RA) and AI, and provide insights into the similarities and differences of cortical and amygdalar regions between birds and mammals. We also propose the use of AMV (instead of nucleus taenia/TnA), AMD, AD, and AI as initial steps toward a universal arcopallial nomenclature. Besides clarifying the internal organization of the arcopallium, the data provide a coherent basis for further functional and comparative studies of this complex avian brain region.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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