Targeting immune cells for cancer therapy.
| Autor: | Gun SY; Singapore Immunology Network, A*STAR, Singapore., Lee SWL; Singapore Immunology Network, A*STAR, Singapore; BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore; Department of Microbiology and Immunology, Yong Loo Ling School of Medicine, National University of Singapore, Singapore., Sieow JL; Singapore Immunology Network, A*STAR, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore., Wong SC; Singapore Immunology Network, A*STAR, Singapore; Department of Microbiology and Immunology, Yong Loo Ling School of Medicine, National University of Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address: wong_siew_cheng@immunol.a-star.edu.sg. |
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| Jazyk: | angličtina |
| Zdroj: | Redox biology [Redox Biol] 2019 Jul; Vol. 25, pp. 101174. Date of Electronic Publication: 2019 Mar 20. |
| DOI: | 10.1016/j.redox.2019.101174 |
| Abstrakt: | Recent years have seen a renaissance in the research linking inflammation and cancer with immune cells playing a central role in smouldering inflammation in the tumor microenvironment. Diverse immune cell types infiltrate the tumor microenvironment, and the dynamic tumor-immune cell interplay gives rise to a rich milieu of cytokines and growth factors. Fundamentally, this intricate cross-talk creates the conducive condition for tumor cell proliferation, survival and metastasis. Interestingly, the prominent impact of immune cells is expounded in their contrary pro-tumoral role, as well as their potential anti-cancer cellular weaponry. The latter is known as immunotherapy, a concept born out of evidence that tumors are susceptible to immune defence and that by manipulating the immune system, tumor growth can be successfully restrained. Naturally, a deeper understanding of the multifaceted roles of various immune cell types thus contributes toward developing innovative anti-cancer strategies. Therefore, in this review we first outline the roles played by the major immune cell types, such as macrophages, neutrophils, natural killer cells, T cells and B cells. We then explain the recently-explored strategies of immunomodulation and discuss some important approaches via an immunology perspective. (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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