| Autor: |
Xia J; Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, 2525 Pottsdamer Street, Tallahassee, Florida 32310-2870, USA. guan@eng.famu.fsu.edu., Tsai AC, Cheng W, Yuan X, Ma T, Guan J |
| Jazyk: |
angličtina |
| Zdroj: |
Biomaterials science [Biomater Sci] 2019 May 28; Vol. 7 (6), pp. 2348-2357. |
| DOI: |
10.1039/c8bm01634h |
| Abstrakt: |
Cell-mediated drug delivery systems utilize living cells as vehicles to achieve controlled delivery of drugs. One of the systems features integrating cells with disk-shaped microparticles termed microdevices into cell-microdevice complexes that possess some unique advantages over their counterparts. Human mesenchymal stem cells (hMSCs) have been extensively studied as therapeutic cells and used as carrier cells for drug-loaded nanoparticles or other functional nanoparticles. This article presents the development of a microdevice-based hMSC-mediated drug delivery system for the first time. This study revealed that the microdevices could be attached to the hMSCs in a controlled and versatile manner; the produced hMSC-microdevice complexes were stable over cultivation and trypsinization, and the microdevice attachment did not affect the viability and proliferation of the hMSCs. Moreover, cultured microdevice-bound hMSCs retained their abilities to migrate on a flat surface, form a spheroid, and actively dissociate from the spheroid. These results indicate that this microdevice-based hMSC-mediated system promises to be further developed into a clinically viable drug delivery system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
