[Serum nesfatin-1 as a marker of systemic inflammation in rheumatoid arthritis.]

Autor:	Kvlividze TZ; The Volgograd State Medical University, 400131, Volgograd, Russian Federation., Zavodovsky BV; The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation., Akhverdyan YR; The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation., Polyakova YV; The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation., Sivordova LE; The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation., Yakovlev AT; The Volgograd State Medical University, 400131, Volgograd, Russian Federation., Zborovskaya IA; The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2019; Vol. 64 (1), pp. 53-56.
DOI:	10.18821/0869-2084-2019-64-1-53-56
Abstrakt:	The purpose of this study was to determine the level of nesfatin-1 (NF-1) in the blood serum of healthy volunteers and patients with rheumatoid arthritis (RA) to establish the threshold for normal values of this parameter and to reveal the relationship between the level of NF-1 and clinical manifestations of RA. We examined 170 people, of which 110 patients with RA and 60 donors who made up the comparison group. The mean level of serum nesfatin-1 in healthy subjects was 31.61 ± 3.17 ng/ml (M ± σ). The level of normal values of nesfatin-1 in healthy individuals, defined as M ± 2σ, was from 25.27 to 37.95 ng/ml. These studies showed the relationship between the concentration of NF-1 and the severity of clinical manifestations of RA. We found that a higher serum level of NF-1 was characteristic of patients with a more severe clinical course of the disease. The data obtained indicate that high level of NF-1 positively correlates with higher concentrations of C-reactive protein and ESR. This data indirectly proves the proinflammatory effect of NF-1 and confirms the hypothesis about the primary role of systemic inflammation in the pathogenesis of RA. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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