Gene cloning to clinical trials-the trials and tribulations of a life with collagen.

Autor: Boot-Handford RP; Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Jazyk: angličtina
Zdroj: International journal of experimental pathology [Int J Exp Pathol] 2019 Feb; Vol. 100 (1), pp. 4-11. Date of Electronic Publication: 2019 Mar 26.
DOI: 10.1111/iep.12311
Abstrakt: This review, based on the BSMB Fell-Muir Lecture I presented in July 2018 at the Matrix Biology Europe Conference in Manchester, gives a personal perspective of my own laboratory's contributions to research into type X collagen, metaphyseal chondrodysplasia type Schmid and potential treatments for this disorder that are currently entering clinical trial. I have tried to set the advances made in the context of the scientific technologies available at the time and how these have changed over the more than three decades of this research.
(© 2019 The Author. International Journal of Experimental Pathology © 2019 International Journal of Experimental Pathology.)
Databáze: MEDLINE
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