Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG + plasma cell persistence in the bone marrow.

Autor:	Männe C; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Takaya A; Department of Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sciences, Chiba University, 263-8522 Chiba, Japan., Yamasaki Y; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Mursell M; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Hojyo S; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Wu TY; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Sarkander J; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., McGrath MA; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Cornelis R; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Hahne S; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Cheng Q; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.; Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Kawamoto T; Radioisotope Research Institute, School of Dental Medicine, Tsurumi University, 230-0063 Yokohama, Japan., Hiepe F; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.; Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Kaufmann SHE; Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany., Yamamoto T; Medical Mycology Research Center, Chiba University, 260-8673 Chiba, Japan., Radbruch A; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany., Tokoyoda K; Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany; tokoyoda@drfz.de.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 09; Vol. 116 (15), pp. 7425-7430. Date of Electronic Publication: 2019 Mar 25.
DOI:	10.1073/pnas.1818242116
Abstrakt:	Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient Salmonella induces high and lasting titers of specific and protective Salmonella -specific IgG and qualifies as an efficient vaccine against Salmonella A SiiE-derived peptide with homology to laminin β1 is sufficient to ablate IgG-secreting plasma cells from the BM, identifying laminin β1 as a component of niches for IgG-secreting plasma cells in the BM, and furthermore, qualifies it as a unique therapeutic option to selectively ablate IgG-secreting plasma cells in autoimmune diseases and multiple myeloma. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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