Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy.

Autor:	Flores-Quijano ME; Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México CP. 11000, Mexico. maru_fq@yahoo.com., Vega-Sánchez R; Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México CP. 11000, Mexico. vegarodrig@gmail.com., Tolentino-Dolores MC; Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México CP. 11000, Mexico. cruz_tolentino@yahoo.com.mx., López-Alarcón MG; Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, CP. 06720, Mexico. marsau2@prodigy.net.mx., Flores-Urrutia MC; Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México CP. 11000, Mexico. fu.monicac@gmail.com., López-Olvera AD; Departamento de Ciencias de la Salud, Universidad del Valle de México, Coyoacán, Ciudad de México, CP. 04910, Mexico. a.daniela.lopez.o@gmail.com., Talavera JO; Dirección de Enseñanza e Investigación. Centro Médico ABC, Ciudad de México, CP. 01120, Mexico. jotalaverap@abchospital.com.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2019 Mar 23; Vol. 11 (3). Date of Electronic Publication: 2019 Mar 23.
DOI:	10.3390/nu11030693
Abstrakt:	The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (sTfr) and serum iron), iron reserves (ferritin), and functional iron (hemoglobin); and (2) to depict the regulating role of hepcidin. The above was carried out while considering influential factors such as initial iron nutrition status, iron intake, and the presence of inflammation. Ninety three non-anemic pregnant adult women were included, 40 with obesity (Ob) and 53 with adequate weight (AW); all took ≈30 mg/day of supplementary iron. Information on iron intake and blood samples were obtained at gestational weeks 13, 20, 27, and 35. A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. Available and circulating iron was lower in obese women: sTfr was higher (p = 0.07) and serum iron was lower (p = 0.01); and ferritin and hemoglobin were not different between groups. Hepcidin was higher in the Ob group (p = 0.01) and was a significant predictor variable for all biomarkers. Obesity during pregnancy dysregulates iron homeostasis, resembling "obesity hypoferremia". Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu