Circadian integration of inflammation and glucocorticoid actions: Implications for the cochlea.

Autor: Sarlus H; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden. Electronic address: heela.sarlus@ki.se., Fontana JM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden., Tserga E; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden., Meltser I; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden., Cederroth CR; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden., Canlon B; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Jazyk: angličtina
Zdroj: Hearing research [Hear Res] 2019 Jun; Vol. 377, pp. 53-60. Date of Electronic Publication: 2019 Mar 15.
DOI: 10.1016/j.heares.2019.03.007
Abstrakt: Auditory function has been shown to be influenced by the circadian system. Increasing evidence point towards the regulation of inflammation and glucocorticoid actions by circadian rhythms in the cochlea. Yet, how these three systems (circadian, immune and endocrine) converge to control auditory function remains to be established. Here we review the knowledge on immune and glucocorticoid actions, and how they interact with the circadian and the auditory system, with a particular emphasis on cochlear responses to noise trauma. We propose a multimodal approach to understand the mechanisms of noise-induced hearing loss by integrating the circadian, immune and endocrine systems into the bearings of the cochlea. Considering the well-established positive impact of chronotherapeutic approaches in the treatment of cardiovascular, asthma and cancer, an increased knowledge on the mechanisms where circadian, immune and glucocorticoids meet in the cochlea may improve current treatments against hearing disorders.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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