Monocyte-Derived CD11c + Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria.

Autor:	Kurup SP; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Anthony SM; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Hancox LS; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Vijay R; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Pewe LL; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Moioffer SJ; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Sompallae R; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Iowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA., Janse CJ; Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center (LUMC), 2333ZA Leiden, the Netherlands., Khan SM; Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center (LUMC), 2333ZA Leiden, the Netherlands., Harty JT; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-harty@uiowa.edu.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2019 Apr 10; Vol. 25 (4), pp. 565-577.e6. Date of Electronic Publication: 2019 Mar 21.
DOI:	10.1016/j.chom.2019.02.014
Abstrakt:	Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria. Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate liver stage of development, and how liver-stage-expressed antigens prime productive CD8 T cell responses remains unknown. We found that a subset of liver-infiltrating monocyte-derived CD11c + cells co-expressing F4/80, CD103, CD207, and CSF1R acquired parasites during the liver stage of malaria, but only after initial hepatocyte infection. These CD11c + cells found in the infected liver and liver-draining lymph nodes exhibited transcriptionally and phenotypically enhanced antigen-presentation functions and primed protective CD8 T cell responses against Plasmodium liver-stage-restricted antigens. Our findings highlight a previously unrecognized aspect of Plasmodium biology and uncover the fundamental mechanism by which CD8 T cell responses are primed against liver-stage malaria antigens. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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