Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus.

Autor:	Mandelbaum G; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Taranda J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Haynes TM; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Hochbaum DR; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Society of Fellows, Harvard University, Cambridge, MA 02138, USA., Huang KW; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Hyun M; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Umadevi Venkataraju K; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Straub C; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Wang W; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Robertson K; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Osten P; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Sabatini BL; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bsabatini@hms.harvard.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2019 May 08; Vol. 102 (3), pp. 636-652.e7. Date of Electronic Publication: 2019 Mar 21.
DOI:	10.1016/j.neuron.2019.02.035
Abstrakt:	The thalamic parafascicular nucleus (PF), an excitatory input to the basal ganglia, is targeted with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore, PF lesions disrupt the execution of correct motor actions in uncertain environments. Nevertheless, the circuitry of the PF and its contribution to action selection are poorly understood. We find that, in mice, PF has the highest density of striatum-projecting neurons among all sub-cortical structures. This projection arises from transcriptionally and physiologically distinct classes of PF neurons that are also reciprocally connected with functionally distinct cortical regions, differentially innervate striatal neurons, and are not synaptically connected in PF. Thus, mouse PF contains heterogeneous neurons that are organized into parallel and independent associative, limbic, and somatosensory circuits. Furthermore, these subcircuits share motifs of cortical-PF-cortical and cortical-PF-striatum organization that allow each PF subregion, via its precise connectivity with cortex, to coordinate diverse inputs to striatum. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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