The changing landscape of live kidney donation in the United States from 2005 to 2017.

Autor: Al Ammary F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Bowring MG; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Massie AB; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland., Yu S; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Waldram MM; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Garonzik-Wang J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Thomas AG; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina., Holscher CM; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Qadi MA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Henderson ML; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wiseman AC; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado., Gralla J; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado., Brennan DC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Segev DL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Scientific Registry of Transplant Recipients, Minneapolis, Minnesota., Muzaale AD; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2019 Sep; Vol. 19 (9), pp. 2614-2621. Date of Electronic Publication: 2019 May 03.
DOI: 10.1111/ajt.15368
Abstrakt: The number of live kidney donors has declined since 2005. This decline parallels the evolving knowledge of risk for biologically related, black, and younger donors. To responsibly promote donation, we sought to identify declining low-risk donor subgroups that might serve as targets for future interventions. We analyzed a national registry of 77 427 donors and quantified the change in number of donors per 5-year increment from 2005 to 2017 using Poisson regression stratified by donor-recipient relationship and race/ethnicity. Among related donors aged <35, 35 to 49, and ≥50 years, white donors declined by 21%, 29%, and 3%; black donors declined by 30%, 31%, and 12%; Hispanic donors aged <35 and 35 to 49 years declined by 18% and 15%, and those aged ≥50 increased by 10%. Conversely, among unrelated donors aged <35, 35 to 49, and ≥50 years, white donors increased by 12%, 4%, and 24%; black donors aged <35 and 35 to 49 years did not change but those aged ≥50 years increased by 34%; Hispanic donors increased by 16%, 21%, and 46%. Unlike unrelated donors, related donors were less likely to donate in recent years across race/ethnicity. Although this decline might be understandable for related younger donors, it is less understandable for lower-risk related older donors (≥50 years). Biologically related older individuals are potential targets for interventions to promote donation.
(© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
Externí odkaz: