Monomicrobial bone and joint infection due to Corynebacterium striatum: literature review and amoxicillin-rifampin combination as treatment perspective.

Autor: Noussair L; Microbiology Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, 104 Bd R. Poincaré, 92380, Garches, France., Salomon E; Microbiology Department, Ambroise Paré University Hospital, APHP, Referral Center for Bone and Joint infection, 9 Av Charles de Gaulle, 92100, Boulogne-Billancourt, France., El Sayed F; Microbiology Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, 104 Bd R. Poincaré, 92380, Garches, France.; Microbiology Department, Ambroise Paré University Hospital, APHP, Referral Center for Bone and Joint infection, 9 Av Charles de Gaulle, 92100, Boulogne-Billancourt, France.; EPIM, UMR INSERM UVSQ U1173 UFR Simone Veil, 2 Avenue de la Source de la Bièvre, 78170, Montigny-le-Bretonneux, France., Duran C; Infectious Disease Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, UVSQ, 104 Bd R. Poincaré, 92380, Garches, France., Bouchand F; Pharmacy Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, 104 Bd R. Poincaré, 92380, Garches, France., Roux AL; Microbiology Department, Ambroise Paré University Hospital, APHP, Referral Center for Bone and Joint infection, 9 Av Charles de Gaulle, 92100, Boulogne-Billancourt, France., Gaillard JL; Microbiology Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, 104 Bd R. Poincaré, 92380, Garches, France.; Microbiology Department, Ambroise Paré University Hospital, APHP, Referral Center for Bone and Joint infection, 9 Av Charles de Gaulle, 92100, Boulogne-Billancourt, France., Bauer T; Orthopaedic Surgery Department, Ambroise Paré University Hospital, APHP, Referral Center For Bone And Joint Infection, 9 Av Charles de Gaulle, 92100, Boulogne-Billancourt, France., Rottman M; Microbiology Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, 104 Bd R. Poincaré, 92380, Garches, France., Dinh A; Infectious Disease Department, Raymond Poincaré University Hospital, APHP, Referral Center for Bone and Joint Infection, UVSQ, 104 Bd R. Poincaré, 92380, Garches, France. aurelien.dinh@aphp.fr.
Jazyk: angličtina
Zdroj: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2019 Jul; Vol. 38 (7), pp. 1269-1278. Date of Electronic Publication: 2019 Mar 22.
DOI: 10.1007/s10096-019-03542-x
Abstrakt: Corynebacterium striatum is a ubiquitous colonizer of human skin and mucous membranes. It is increasingly involved in infections, especially with prosthetic devices or in immunocompromised individuals. Microbiological diagnosis is challenging and bacterial resistance is a major concern. We performed a retrospective study of monomicrobial bone and joint infections (BJI) due to C. striatum in two referral centers from April 2012 to July 2017. We collected the patients' clinical and microbiological characteristics and outcomes. We also performed a literature review of BJI due to C. striatum. We identified 12 cases (nine prosthetic joint infections, one osteosynthetic device infection, one non-union, and one arthritis) in 11 patients, five of which were immunocompromised. Microbiological diagnosis was performed with prolonged culture media. Ten out of 12 strains were susceptible to aminopenicillin, a drug class not recommended for testing by the EUCAST/CASFM guidelines, and 8/12 patients were treated with amoxicillin-rifampicin. The cure rate was 8/12, after a median follow-up period of 487.5 days (IQR 140.3-1348.5). Twelve cases of BJI due to C. striatum were previously reported. Among them, 5/12 patients were immunocompromised, 3/12 cases were acute BJI, and 2/12 were device-related infections. The diagnosis was performed by PCR in one case, and 10/12 patients were treated with glycolipopeptides, with a cure rate of 11/12. We report the largest cohort of monomicrobial BJI with C. striatum. Determination of aminopenicillin susceptibility is essential since it is frequently active in our experience, even in BJI. The cure rate of this infection seems high.
Databáze: MEDLINE
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