Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin.

Autor: Men'shchikova EB; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. lemen@centercem.ru., Zenkov NK; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Kozhin PM; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Chechushkov AV; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Kovner AV; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Khrapova MV; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Kandalintseva NV; Novosibirsk State Pedagogical University, Novosibirsk, Russia., Martinovich GG; Belarusian State University, Minsk, Republic of Belarus.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Mar; Vol. 166 (5), pp. 646-650. Date of Electronic Publication: 2019 Mar 22.
DOI: 10.1007/s10517-019-04410-6
Abstrakt: ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a cumulative dose of 8 mg/kg were followed by inhibition of tumor growth by 49.5%. Combined treatment with TS-13 and doxorubicin suppressed the tumor growth by 55.4%. In contrast to doxorubicin, TS-13 inhibited NO generation by peritoneal macrophages. The results show the prospect of studying TS-13 in the context of overcoming drug-resistance of tumors.
Databáze: MEDLINE
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