The Utility of Soluble CD14 Subtype in Early Diagnosis of Culture-Proven Early-Onset Neonatal Sepsis and Prediction of Outcome.
| Autor: | Gad GI; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Shinkar DM; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Kamel El-Din MM; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Nagi HM; Egyptian Ministry of Health, Cairo, Egypt. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | American journal of perinatology [Am J Perinatol] 2020 Apr; Vol. 37 (5), pp. 497-502. Date of Electronic Publication: 2019 Mar 21. |
| DOI: | 10.1055/s-0039-1683863 |
| Abstrakt: | Objective: This study aimed to evaluate soluble cluster of differentiation 14 subtype (sCD14-ST), also named presepsin, as an early marker for the diagnosis of culture-proven early-onset sepsis (EOS) in neonates and to assess its relation to disease severity and mortality. Study Design: Out of 60 neonates with risk factors of EOS, 31 neonates were diagnosed as having culture-proven EOS. They were compared with 20 nonseptic controls. We obtained blood samples on day 1 of life for sCD14-ST measurement and sepsis screening. Blood samples were repeated on day 3 in EOS neonates. Results: sCD14-ST was significantly higher in EOS neonates than controls ( p < 0.001). Neonates who later developed septic shock had significantly higher day 1 sCD14-ST level than those who did not ( p < 0.001). Furthermore, neonates who died had significantly higher day 1 sCD14-ST than survivors ( p < 0.001). On day 3, there was a significant decline in sCD14-ST levels than initial levels among survivors. There was a significant positive correlation between day 1 sCD14-ST level and Tollner's sepsis severity score. Conclusion: sCD14-ST could be used as a powerful diagnostic and prognostic marker of EOS. Its quantitative measurement at birth could be a good predictor of sepsis severity and mortality. Competing Interests: None declared. (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|