Diagnostic accuracy of non-contrast magnetic resonance enterography in detecting active bowel inflammation in pediatric patients with diagnosed or suspected inflammatory bowel disease to determine necessity of gadolinium-based contrast agents.

Autor: Kim SJ; Department of Radiology, SSM Saint Louis University Hospital, Saint Louis University School of Medicine, 3635 Vista Ave. at Grand Boulevard, St. Louis, MO, 63110, USA., Ratchford TL; Department of Gastroenterology, SSM Health Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, 1465 S. Grand Blvd., St. Louis, MO, 63104, USA., Buchanan PM; Center of Health Outcomes Research, Saint Louis University, 3545 Lafayette Ave., St. Louis, MO, 63104, USA., Patel DR; Department of Gastroenterology, SSM Health Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, 1465 S. Grand Blvd., St. Louis, MO, 63104, USA., Tao TY; Department of Radiology, SSM Health Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, 1465 S. Grand Blvd., St. Louis, MO, 63104, USA., Teckman JH; Department of Gastroenterology, SSM Health Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, 1465 S. Grand Blvd., St. Louis, MO, 63104, USA., Brown JJ; Department of Radiology, SSM Saint Louis University Hospital, Saint Louis University School of Medicine, 3635 Vista Ave. at Grand Boulevard, St. Louis, MO, 63110, USA., Farmakis SG; Department of Radiology, SSM Health Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, 1465 S. Grand Blvd., St. Louis, MO, 63104, USA. shannon.farmakis@health.slu.edu.
Jazyk: angličtina
Zdroj: Pediatric radiology [Pediatr Radiol] 2019 May; Vol. 49 (6), pp. 759-769. Date of Electronic Publication: 2019 Mar 21.
DOI: 10.1007/s00247-019-04369-6
Abstrakt: Background: Pediatric patients with inflammatory bowel disease (IBD) are at increased risk of gadolinium deposition given the potential need for multiple contrast-enhanced magnetic resonance enterography (MRE) exams over their lifetime.
Objective: To determine whether gadolinium-based contrast agents are necessary in assessing active bowel inflammation on MRE in pediatric patients with known or suspected IBD.
Materials and Methods: We conducted a retrospective study of 77 patients (7-18 years; 68.8% male) with known (n=58) or suspected (n=19) IBD and endoscopy with biopsy performed within 30 days of MRE without and with contrast evaluated bowel and non-bowel findings. During three visual analysis sessions, two radiologists reviewed pre-, post-, and pre-/post-contrast MRE images. A third radiologist independently reviewed 27 studies to assess inter-reader reliability. We used Cohen kappa (κ), Fleiss kappa, (κ F ), McNemar test, and sensitivity and specificity to compare MRE readings to combined endoscopic/histopathological findings (the reference standard).
Results: The pre- and pre-/post-contrast-enhanced MRE vs. combined endoscopic/histopathological results had moderate agreement (85.7%; κ 0.713, P<0.001; P-value 0.549). Compared to combined endoscopy/histopathology, pre- vs. pre-/post-contrast sensitivity (67%, confidence interval [CI] 0.53-0.79 vs. 67%, CI 0.53-0.79) and specificity (80%, CI 0.59-0.92 vs. 68%, CI 0.46-0.84) varied little (κ 0.42, P<0.001 and κ 0.32, P=0.003, respectively). The three readers had moderate agreement (85.2%; κ 0.695, P=0.001; P-value 0.625). More penetrating complications were identified following contrast administration (P-value 0.04).
Conclusion: Use of a contrast agent does not improve the detection of active inflammation in the terminal ileum and colon compared to non-contrast MRE, although use of a contrast agent does aid in the detection of penetrating disease.
Databáze: MEDLINE
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