High Prevalence of CKD of Unknown Etiology in Uddanam, India.

Autor:	Tatapudi RR; GITAM Institute of Medical Sciences and Research, GITAM deemed to be University, Gandhi Nagar, Visakhapatnam, India., Rentala S; Department of Biotechnology, GITAM Institute of Technology, GITAM deemed to be University, Gandhi Nagar, Visakhapatnam, India., Gullipalli P; Department of Nephrology, Andhra Medical College, Visakhapatnam, India., Komarraju AL; GITAM Institute of Science, GITAM deemed to be University, Gandhi Nagar, Visakhapatnam, India., Singh AK; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Tatapudi VS; Department of Medicine, NYU Langone Transplant Institute, NYU Langone Health, New York, New York, USA., Goru KB; Department of Social and Preventive Medicine, Rangaraya Medical College, Kakinada, Andhra Pradesh, India., Bhimarasetty DM; Department of Community Medicine, Andhra Medical College, Visakhapatnam, India., Narni H; Department of Community Medicine, Gayatri Vidya Parishad Institute of Health Care and Medical Technology, Visakhapatnam, India.
Jazyk:	angličtina
Zdroj:	Kidney international reports [Kidney Int Rep] 2018 Oct 16; Vol. 4 (3), pp. 380-389. Date of Electronic Publication: 2018 Oct 16 (Print Publication: 2019).
DOI:	10.1016/j.ekir.2018.10.006
Abstrakt:	Introduction: There were concerns raised regarding a high prevalence of chronic kidney disease (CKD) in Uddanam, a fertile subtropical low-altitude territory in the southern Indian state of Andhra Pradesh. The present study was undertaken to ascertain the prevalence of CKD, disease characteristics, and risk factor profile in this area. Methods: We selected 2210 subjects (age >18 years) using multistage sampling. After obtaining demographic and anthropometric data, urinary protein-creatinine ratio, serum creatinine, and blood glucose were measured in all the subjects. Glomerular filtration rate was estimated (eGFR) using the Modification of Diet in Renal Disease equation. Results: Mean age of the subjects was 43.2 ± 14.2 years (range: 18-98), 44.3% were men and 55.7% were women. Mean eGFR of subjects was 94.3 ± 33.4. Low eGFR (<60 ml/min per 1.73 m 2 ) was seen in 307 (13.98%) patients with a mean eGFR of 34.8 ± 16.6. The prevalence of subjects having low eGFR and with proteinuria (CKD) was 18.23%. Major risk factors, such as diabetes, long-standing hypertension, and significant proteinuria, were absent in 73% of patients with CKD, implying that a significant proportion of the population is afflicted with the entity "CKD of unknown etiology (CKDu)." Conclusion: The prevalence of CKD and CKDu in Uddanam is much higher than other earlier studies in either rural or urban communities in India. We suggest that there is a dire need to review health policies and allocate resources for prevention and treatment of CKD in the Uddanam region.
Databáze:	MEDLINE
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