Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis.

Autor: Sun M; College of Optometry, University of Houston, Houston, Texas, United States., Puri S; College of Optometry, University of Houston, Houston, Texas, United States., Mutoji KN; College of Optometry, University of Houston, Houston, Texas, United States., Coulson-Thomas YM; Universidade Federal de São Paulo, São Paulo, Brazil., Hascall VC; Cleveland Clinic, Cleveland, Ohio, United States., Jackson DG; MRC Human Immunology Unit, University of Oxford, Oxford, United Kingdom., Gesteira TF; College of Optometry, University of Houston, Houston, Texas, United States.; Universidade Federal de São Paulo, São Paulo, Brazil., Coulson-Thomas VJ; College of Optometry, University of Houston, Houston, Texas, United States.
Jazyk: angličtina
Zdroj: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2019 Mar 01; Vol. 60 (4), pp. 1050-1062.
DOI: 10.1167/iovs.18-25920
Abstrakt: Purpose: We recently reported that the glycosaminoglycan hyaluronan (HA), which promotes inflammatory angiogenesis in other vascular beds, is an abundant component of the limbal extracellular matrix. Consequently, we have explored the possibility that HA contributes to lymphangiogenesis in the inflamed cornea.
Methods: To study the role of HA on lymphangiogenesis, we used mice lacking the hyaluronan synthases and injury models that induce lymphangiogenesis.
Results: Here we report that HA regulates corneal lymphangiogenesis, both during post-natal development and in response to adult corneal injury. Furthermore, we show that injury to the cornea by alkali burn upregulates both HA production and lymphangiogenesis and that these processes are ablated in HA synthase 2 deficient mice.
Conclusion: These findings raise the possibility that therapeutic blockade of HA-mediated lymphangiogenesis might prevent the corneal scarring and rejection that frequently results from corneal transplantation.
Databáze: MEDLINE
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