An assessment of bacterial overgrowth and translocation in the non-alcoholic fatty liver of patients with morbid obesity.

Autor:	Domper Bardají F; Aparato Digestivo , Hospital General Universitario de Ciudad Real, España., Gil Rendo A; Cirugía General, Hospital General Universitario de Ciudad Real., Illescas Fernández-Bermejo S; Microbiología, Hospital General Universitario de Ciudad Real., Patón Arenas R; Aparato Digestivo, Hospital General Universitario de Ciudad Real, ESPAÑA., Hernández Albújar A; Aparato Digestivo, Hospital General Universitario de Ciudad Real., Martín Dávila F; Anatomía Patológica, Hospital General Universitario de Ciudad Real., Murillo Lázaro C; Anatomía Patológica, Hospital General Universitario de Ciudad Real., Sánchez Alonso M; Aparato Digestivo, Hospital General Universitario de Ciudad Real, España., Serrano Dueñas M; Aparato Digestivo, Hospital General Universitario de Ciudad Real., Sobrino López A; Aparato Digestivo, Hospital General Universitario de Ciudad Real., Ramírez Esteso F; Aparato Digestivo, Hospital General Universitario de Ciudad Real., Martín Fernández J; Cirugía General, Hospital General Universitario Ciudad Real.
Jazyk:	angličtina
Zdroj:	Revista espanola de enfermedades digestivas [Rev Esp Enferm Dig] 2019 Apr; Vol. 111 (4), pp. 294-300.
DOI:	10.17235/reed.2019.5942/2018
Abstrakt:	Background: small intestinal bacterial overgrowth (SIBO) and bacterial translocation across the intestinal wall have been allegedly associated with non-alcoholic fatty liver (NAFL). Our goal was to study such alleged association in morbidly obese patients. Patients and Methods: patients with morbid obesity were consecutively included prior to bariatric surgery. Exclusion criteria included normal liver biopsy, other causes of liver disease, and duodenal mucosal atrophy. A gastroscopy was performed for duodenal aspirate culture and duodenal biopsy, and peripheral venous blood was drawn to assess lipopolysaccharide (LPS) and LPS-binding protein (LBP) levels. A liver biopsy was carried out during surgery. Results: seventy-one patients were included; 26 were excluded because of normal liver biopsy. Forty-five had NAFL. Eighteen were male, mean age was 45.8 years (22-69), and BMI was 47.8 kg/m2 (37-58). A total of 25% had SIBO in their duodenal aspirate culture. There was statistical significance for the association of LBP levels and SIBO with steatosis grade (p < 0.05 and p = 0.077, respectively). There was no statistical association with non-alcoholic steatohepatitis (NASH) index, but a trend towards association was found. LPS levels were not associated with steatosis grade or NASH index. Conclusions: the higher the grade of liver steatosis, the higher were the circulating LBP levels and SIBO rates seen in patients with morbid obesity and NAFL.
Databáze:	MEDLINE
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