Emerging role for Ureaplasma parvum serovar 3: Active infection in women with silent high-risk human papillomavirus and in women with idiopathic infertility.

Autor: Zanotta N; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Campisciano G; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Morassut S; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Castro-Silva E; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Luksa V; Department of Medical Sciences, University of Trieste, Trieste, Italy., Zito G; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Luppi S; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Martinelli M; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Colli C; MST Centre, ASUITS, Trieste, Italy., De Seta F; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Ricci G; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Suligoi B; Istituto Superiore di Sanità, Rome, Italy., Comar M; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2019 Aug; Vol. 234 (10), pp. 17905-17911. Date of Electronic Publication: 2019 Mar 18.
DOI: 10.1002/jcp.28423
Abstrakt: Recently, there are controversial opinions on the presence of Mycoplasmas/Ureaplasmas as colonizers or pathogens, and on the use of a targeted therapy. This study aimed to characterize Mycoplasmas/Ureaplasmas infections in reproductive age women, including the acquisition of sexually transmitted (ST) pathogens and poor birth outcomes. A total of 646 healthy Italian women fulfilled the inclusion criteria including 521 infertile women, 65 pregnant women, and 60 fertile women with identified risk factors and symptomatic for vaginitis/cervicitis. Multiplex and quantitative molecular techniques and direct automatic DNA sequencing were performed to assess the genome structure of Mycoplasma/Ureaplasma species and ST infected pathogens. Ureaplasma parvum serovar 3 represented the predominant colonizer of the urogenital tract of this series and the unique species significantly associated with ST pathogens coinfection (p < 0.01). U. parvum load >10 4 bacteria/ml, suggestive of active infection, has been measured only in asymptomatic high-risk human papillomavirus infected women (24.3%) and in 40% of women with idiopathic infertility. To note, 16% of the follicular fluid from these idiopathic women resulted infected with U. parvum. In conclusion, the present study focused the attention on U. parvum serovar 3 as emerging microorganism in sexually active women that may have the benefit of targeted therapy.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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