Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium.

Autor:	Leon ME; Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France., Schinasi LH; Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France.; Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA, USA., Lebailly P; ANTICIPE, U1086 INSERM, Université de Caen Normandie, and Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Beane Freeman LE; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), Bethesda, MD, USA., Nordby KC; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health (STAMI), Oslo, Norway., Ferro G; Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France., Monnereau A; Hematological Malignancies Registry of Gironde, Bergonie Institute, Comprehensive Cancer Centre, Bordeaux, France.; University of Bordeaux, INSERM U1219 Center - EPICENE Team, CHU de Bordeaux, Bordeaux, France., Brouwer M; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Tual S; ANTICIPE, U1086 INSERM, Université de Caen Normandie, and Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Baldi I; CHU de Bordeaux, Service de Médecine du Travail et Pathologie Professionnelle, Bordeaux, France., Kjaerheim K; Department of Research, Cancer Registry of Norway, Oslo, Norway., Hofmann JN; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), Bethesda, MD, USA., Kristensen P; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health (STAMI), Oslo, Norway., Koutros S; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), Bethesda, MD, USA., Straif K; Section of Evidence Synthesis and Classification, International Agency for Research on Cancer (IARC), Lyon, France., Kromhout H; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Schüz J; Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France.
Jazyk:	angličtina
Zdroj:	International journal of epidemiology [Int J Epidemiol] 2019 Oct 01; Vol. 48 (5), pp. 1519-1535.
DOI:	10.1093/ije/dyz017
Abstrakt:	Background: Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers. Methods: We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA). Cox regression models were used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), which were combined using random effects meta-analysis to calculate meta-HRs. Results: During follow-up, 2430 NHL cases were diagnosed in 316 270 farmers accruing 3 574 815 person-years under risk. Most meta-HRs suggested no association. Moderately elevated meta-HRs were seen for: NHL and ever use of terbufos (meta-HR = 1.18, 95% CI: 1.00-1.39); chronic lymphocytic leukaemia/small lymphocytic lymphoma and deltamethrin (1.48, 1.06-2.07); and diffuse large B-cell lymphoma and glyphosate (1.36, 1.00-1.85); as well as inverse associations of NHL with the broader groups of organochlorine insecticides (0.86, 0.74-0.99) and phenoxy herbicides (0.81, 0.67-0.98), but not with active ingredients within these groups, after adjusting for exposure to other pesticides. Conclusions: Associations of pesticides with NHL appear to be subtype- and chemical-specific. Non-differential exposure misclassification was an important limitation, showing the need for refinement of exposure estimates and exposure-response analyses. (© World Health Organization, 2019. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.)
Databáze:	MEDLINE
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