More Than 25 Years Together: Basis for a Long-Lifespan Kidney Transplant.

Autor: Díaz LS; Nephrology Department, HUCA, Oviedo, Spain. Electronic address: lucia.sobrino@gmail.com., Fraile MG; Nephrology Department, HUCA, Oviedo, Spain; Red Investigación Renal (REDINREN), Madrid, Spain., López ACA; Nephrology Department, HUCA, Oviedo, Spain., Fernández MLS; Nephrology Department, HUCA, Oviedo, Spain; Red Investigación Renal (REDINREN), Madrid, Spain., Cano NR; Nephrology Department, HUCA, Oviedo, Spain., Díaz-Corte C; Nephrology Department, HUCA, Oviedo, Spain; Red Investigación Renal (REDINREN), Madrid, Spain.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2019 Mar; Vol. 51 (2), pp. 334-336. Date of Electronic Publication: 2018 Oct 28.
DOI: 10.1016/j.transproceed.2018.10.007
Abstrakt: Patients with graft survival for 20 years or more are not uncommon; they are called ultralong kidney recipients. It is interesting to know if there are patterns in donors and recipients that could be reproduced. A retrospective cohort with 22 adult patients with a kidney renal transplant performed more than 25 years ago is analyzed. The mean of age of the donors was 24 years (median, 21 years); 82% were men and the cause of death was mainly acute traumatic brain injury. Recipients had a mean age of 34 years (median, 36 years) at the time of transplant; the most common underlying renal disease was glomerular, without evidence of recurrence. A total of 16 patients had compatibility in HLA II (1 in 11 cases; 2 in 5 cases). Only 6 patients have had any episode of acute rejection; 3 of them have developed antibodies class I, but no donor-specific antibodies. In this retrospective cohort, increases in donor age are associated with poor renal function. The mean creatinine is 1.43 mg/dL (range, 0.97-2.14 mg/dL) and mean proteinuria is 653.43 mg/g (range, 55-3722 mg/g). The characteristics common in ultralong kidney recipients are young male donors, a shortage of episodes of rejection, and good HLA compatibility, especially in class II antigens.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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