Comparison of hyperspectral imaging techniques for the elucidation of falsified medicines composition.

Autor: Coic L; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium. Electronic address: laureen.coic@uliege.be., Sacré PY; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium. Electronic address: pysacre@uliege.be., Dispas A; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium., Sakira AK; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium; Université Ouaga 1 Pr Joseph KI-ZERBO, Ouagadougou, Burkina Faso., Fillet M; University of Liege (ULiege), CIRM, Laboratory of the Analysis of Medicines, Department of Pharmacy, CHU, B36, 4000 Liege, Belgium., Marini RD; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium., Hubert P; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium., Ziemons E; University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2019 Jun 01; Vol. 198, pp. 457-463. Date of Electronic Publication: 2019 Feb 08.
DOI: 10.1016/j.talanta.2019.02.032
Abstrakt: Hyperspectral imaging has shown a high potential to analyze falsifications of solid pharmaceutical products since the last decade. Thanks to the non-destructive, ecological and non-invasive properties, it is a preferred technique for these kinds of applications. Moreover, thanks to the spectroscopic properties, it is possible to detect as well organic compounds as inorganic compounds in a single analysis. Therefore, we recommend using it as second-line laboratory analysis technique. Raman microscopy and Fourier Transform Infrared (FT-IR) microscopy are two interesting techniques that are complementary. In this study, the potential of the two hyperspectral imaging techniques is evaluated to elucidate the composition of falsified antimalarial tablets. Hyperspectral data are analyzed by Multivariate Curve Resolution-Alternating Least Square (MCR-ALS). The results obtained from this study show that Raman hyperspectral imaging seems to be more suited to detect low dosed compounds possibly due to a smallest sampling volume. It has been also possible to link formulations of falsified samples of two different brands.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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