Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex.

Autor: Wang H; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States., Jordan VC; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States.; Institute for Innovation in Imaging, Department of Radiology , Massachusetts General Hospital , 55 Fruit Street , Boston , Massachusetts 02114 , United States., Ramsay IA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States., Sojoodi M; Division of Surgical Oncology , Massachusetts General Hospital/Harvard Medical School , WRN401, 55 Fruit Street , Boston , Massachusetts 02114 , United States., Fuchs BC; Division of Surgical Oncology , Massachusetts General Hospital/Harvard Medical School , WRN401, 55 Fruit Street , Boston , Massachusetts 02114 , United States., Tanabe KK; Division of Surgical Oncology , Massachusetts General Hospital/Harvard Medical School , WRN401, 55 Fruit Street , Boston , Massachusetts 02114 , United States., Caravan P; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States.; Institute for Innovation in Imaging, Department of Radiology , Massachusetts General Hospital , 55 Fruit Street , Boston , Massachusetts 02114 , United States., Gale EM; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States.
Jazyk: angličtina
Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2019 Apr 10; Vol. 141 (14), pp. 5916-5925. Date of Electronic Publication: 2019 Mar 28.
DOI: 10.1021/jacs.9b00603
Abstrakt: We introduce a redox-active iron complex, Fe-PyC3A, as a biochemically responsive MRI contrast agent. Switching between Fe 3+ -PyC3A and Fe 2+ -PyC3A yields a full order of magnitude relaxivity change that is field-independent between 1.4 and 11.7 T. The oxidation of Fe 2+ -PyC3A to Fe 3+ -PyC3A by hydrogen peroxide is very rapid, and we capitalized on this behavior for the molecular imaging of acute inflammation, which is characterized by elevated levels of reactive oxygen species.  Injection of Fe 2+ -PyC3A generates strong, selective contrast enhancement of inflamed pancreatic tissue in a mouse model (caerulein/LPS model). No significant signal enhancement is observed in normal pancreatic tissue (saline-treated mice). Importantly, signal enhancement of the inflamed pancreas correlates strongly and significantly with ex vivo quantitation of the pro-inflammatory biomarker myeloperoxidase. This is the first example of using metal ion redox for the MR imaging of pathologic change in vivo. Redox-active Fe 3+/2+ complexes represent a new design paradigm for biochemically responsive MRI contrast agents.
Databáze: MEDLINE
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