Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia.

Autor: Geaghan MP; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia., Atkins JR; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia., Brichta AM; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia., Tooney PA; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia., Scott RJ; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Information Based Medicine, Hunter Medical Research Institute, New Lambton, New South Wales, Australia., Carr VJ; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Department of Psychiatry, School of Clinical Sciences, Monash University, VIC, Australia., Cairns MJ; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia. Electronic address: murray.cairns@newcastle.edu.au.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2019 May; Vol. 112, pp. 89-98. Date of Electronic Publication: 2019 Mar 05.
DOI: 10.1016/j.jpsychires.2019.02.023
Abstrakt: The aetiology of schizophrenia is complex, heterogeneous, and involves interplay of many genetic and environmental influences. While significant progress has been made in the understanding the common heritable component, we are still grappling with the genomic encoding of environmental risk. One class of molecule that has tremendous potential is miRNA. These molecules are regulated by genetic and environmental factors associated with schizophrenia and have a very significant impact on temporospatial patterns of gene expression. To better understand the relationship between miRNA and gene expression in the disorder we analysed these molecules in RNA isolated from peripheral blood mononuclear cells (PBMCs) obtained from an Australian cohort of 36 individuals with schizophrenia and 15 healthy controls using next-generation RNA sequencing. Significant changes in both mRNA and miRNA expression profiles were observed implicating important interaction networks involved in immune activity and development. We also observed sexual dimorphism, particularly in relation to variation in mRNA, with males showing significantly more differentially expressed genes. Interestingly, while we explored expression in lymphocytes, the systems biology of miRNA-mRNA interactions was suggestive of significant pleiotropy with enrichment of networks related to neuronal activity.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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