Walking and postural balance in adults with severe short stature due to isolated GH deficiency.

Autor:	Santana-Ribeiro AA; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil., Moreira-Brasileiro GA; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil.; Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Salvatori R; Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Carvalho VO; Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil., Alvim-Pereira CK; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil., Araújo-Daniel CR; Department of Statistic and Actuarial Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Reis-Costa JG; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil., Andrade-Guimarães AL; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil.; Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil., Oliveira-Santos AA; Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Vieira ER; Department of Physical Therapy and Neuroscience, Wertheims' College of Nursing and Health Science, Florida International University, Miami, Florida, USA., Gois-Junior MB; Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil.; Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil.; Department of Physical Therapy and Neuroscience, Wertheims' College of Nursing and Health Science, Florida International University, Miami, Florida, USA.
Jazyk:	angličtina
Zdroj:	Endocrine connections [Endocr Connect] 2019 Apr; Vol. 8 (4), pp. 416-424.
DOI:	10.1530/EC-19-0103
Abstrakt:	Objectives: Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since GH and IGF-I act on all these systems, we decided to study those parameters in a cohort of individuals with severe short stature due to untreated isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor gene. These IGHD subjects, despite reduction in muscle mass, are very active and have normal longevity. Methods: In a cross-sectional study, we assessed walking (by a 6-min walk test), postural balance (by force platform) and fall risk (by the 'Timed Up and Go' test) in 31 IGHD and 40 matched health controls. Results: The percentage of the walked distance measured in relation to the predicted one was similar in groups, but higher in IGHD, when corrected by the leg length. Absolute postural balance data showed similar velocity of unipodal support in the two groups, and better values, with open and closed eyes and unipodal support, in IGHD, but these differences became non-significant when corrected for height and lower-limb length. The time in 'Timed Up and Go' test was higher in IGHD cohort, but still below the cut-off value for fall risk. Conclusion: IGHD subjects exhibit satisfactory walking and postural balance, without increase in fall risk.
Databáze:	MEDLINE
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