The Stem Cell Phenotype of Aggressive Breast Cancer Cells.

Autor: Margaryan NV; Department of Biochemistry, West Virginia University, Morgantown, WV 26506, USA. naira.margaryan@hsc.wvu.edu.; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. naira.margaryan@hsc.wvu.edu., Hazard-Jenkins H; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. hhazard@hsc.wvu.edu.; Department of Surgery, West Virginia University, Morgantown, WV 26506, USA. hhazard@hsc.wvu.edu., Salkeni MA; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. mosalkeni@hsc.wvu.edu.; Department of Internal Medicine, West Virginia University, Morgantown, WV 26506, USA. mosalkeni@hsc.wvu.edu., Smolkin MB; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. mbsmolkin@hsc.wvu.edu.; Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA. mbsmolkin@hsc.wvu.edu., Coad JA; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. jcoad@hsc.wvu.edu.; Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA. jcoad@hsc.wvu.edu., Wen S; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. siwen@hsc.wvu.edu.; Department of Biostatistics, School of Public Health, West Virginia University, Morgantown, WV 26506, USA. siwen@hsc.wvu.edu., Seftor EA; Department of Biochemistry, West Virginia University, Morgantown, WV 26506, USA. elisabeth.seftor@hsc.wvu.edu.; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. elisabeth.seftor@hsc.wvu.edu., Seftor REB; Department of Biochemistry, West Virginia University, Morgantown, WV 26506, USA. richard.seftor@hsc.wvu.edu.; West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA. richard.seftor@hsc.wvu.edu., Hendrix MJC; Department of Biology, Shepherd University, Shepherdstown, WV 25443, USA. mhendrix@shepherd.edu.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2019 Mar 08; Vol. 11 (3). Date of Electronic Publication: 2019 Mar 08.
DOI: 10.3390/cancers11030340
Abstrakt: Aggressive cancer cells are characterized by their capacity to proliferate indefinitely and to propagate a heterogeneous tumor comprised of subpopulations with varying degrees of metastatic propensity and drug resistance properties. Particularly daunting is the challenge we face in the field of oncology of effectively targeting heterogeneous tumor cells expressing a variety of markers, especially those associated with a stem cell phenotype. This dilemma is especially relevant in breast cancer, where therapy is based on traditional classification schemes, including histological criteria, differentiation status, and classical receptor markers. However, not all patients respond in a similar manner to standard-of-care therapy, thereby necessitating the need to identify and evaluate novel biomarkers associated with the difficult-to-target stem cell phenotype and drug resistance. Findings related to the convergence of embryonic and tumorigenic signaling pathways have identified the embryonic morphogen Nodal as a promising new oncofetal target that is reactivated only in aggressive cancers, but not in normal tissues. The work presented in this paper confirms previous studies demonstrating the importance of Nodal as a cancer stem cell molecule associated with aggressive breast cancer, and advances the field by providing new findings showing that Nodal is not targeted by standard-of-care therapy in breast cancer patients. Most noteworthy is the linkage found between Nodal expression and the drug resistance marker ATP-binding cassette member 1 (ABCA1), which may provide new insights into developing combinatorial approaches to overcome drug resistance and disease recurrence.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje