Chronic long-term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort.

Autor: Amadou A; Department of Cancer and Environment, Centre Léon Bérard, Lyon, France.; Inserm UA 08 Radiations: Défense, Santé, Environnement, 69008 Lyon, France., Praud D; Department of Cancer and Environment, Centre Léon Bérard, Lyon, France.; Inserm U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Cancer Research Center of Lyon, Lyon, France., Coudon T; Department of Cancer and Environment, Centre Léon Bérard, Lyon, France.; Ecole Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecully, France., Danjou AMN; Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France., Faure E; Department of Cancer and Environment, Centre Léon Bérard, Lyon, France., Leffondré K; Université de Bordeaux, ISPED, Centre Inserm U1219 Bordeaux Population Health, Bordeaux, France., Le Romancer M; Inserm U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Cancer Research Center of Lyon, Lyon, France., Severi G; Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France., Salizzoni P; Ecole Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecully, France., Mancini FR; Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France., Fervers B; Department of Cancer and Environment, Centre Léon Bérard, Lyon, France.; Inserm UA 08 Radiations: Défense, Santé, Environnement, 69008 Lyon, France.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2020 Jan 15; Vol. 146 (2), pp. 341-351. Date of Electronic Publication: 2019 Apr 01.
DOI: 10.1002/ijc.32257
Abstrakt: Cadmium, due to its estrogen-like activity, has been suspected to increase the risk of breast cancer; however, epidemiological studies have reported inconsistent findings. We conducted a case-control study (4,059 cases and 4,059 matched controls) nested within the E3N French cohort study to estimate the risk of breast cancer associated with long-term exposure to airborne cadmium pollution, and its effect according to molecular subtype of breast cancer (estrogen receptor negative/positive [ER-/ER+] and progesterone receptor negative/positive [PR-/PR+]). Atmospheric exposure to cadmium was assessed using a Geographic Information System-based metric, which included subject's residence-to-cadmium source distance, wind direction, exposure duration and stack height. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Overall, there was no significant association between cumulative dose of airborne cadmium exposure and the risk of overall, premenopausal and postmenopausal breast cancer. However, by ER and PR status, inverse associations were observed for ER- (OR Q5 vs. Q1  = 0.63; 95% CI: 0.41-0.95, p trend  = 0.043) and for ER-/PR- breast tumors (OR Q4 vs. Q1  = 0.62; 95% CI: 0.40-0.95, OR Q5 vs. Q1  = 0.68; 95% CI: 0.42-1.07, p trend  = 0.088). Our study provides no evidence of an association between exposure to cadmium and risk of breast cancer overall but suggests that cadmium might be related to a decreased risk of ER- and ER-/PR- breast tumors. These observations and other possible effects linked to hormone receptor status warrant further investigations.
(© 2019 UICC.)
Databáze: MEDLINE
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