Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study.

Autor:	Verreijen AM; Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands., Engberink MF; Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands., Houston DK; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC., Brouwer IA; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands., Cawthon PM; California Pacific Medical Center Research Institute, San Francisco, CA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA., Tylavsky FA; Health Science Center, Preventive Medicine, University of Tennessee, Memphis, TN., Harris TB; National Institute on Aging, Bethesda, MD., Weijs PJM; Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands.; Nutrition and Dietetics, Department of Internal Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Visser M; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2019 Mar 01; Vol. 109 (3), pp. 535-543.
DOI:	10.1093/ajcn/nqy341
Abstrakt:	Background: A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. Objectives: We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). Methods: Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. Results: Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was -9.8 (-10.6, -8.9) cm2. No association was observed between energy-adjusted total (β = -0.00; 95% CI: -0.06, 0.06 cm2; P = 0.982), animal (β = -0.00; 95% CI: -0.06, 0.05 cm2; P = 0.923), or plant (β = +0.07; 95% CI: -0.06, 0.21 cm2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. Conclusions: This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930. (© 2019 American Society for Nutrition.)
Databáze:	MEDLINE
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