Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection.

Autor: Li Y; Research Center for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China., Ma Y; MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China., Jiao X; Research Center for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China., Li T; MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China., Lv Z; MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China., Yang CJ; MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China. cyyang@xmu.edu.cn.; Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200127, PR China. cyyang@xmu.edu.cn., Zhang X; Research Center for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China. zhangxueji@ustb.edu.cn., Wen Y; Research Center for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China. wyq_wen@ustb.edu.cn.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2019 Mar 08; Vol. 10 (1), pp. 1036. Date of Electronic Publication: 2019 Mar 08.
DOI: 10.1038/s41467-019-08952-1
Abstrakt: DNA hydrogels have received considerable attention in analytical science, however, some limitations still exist in the applications of intelligent hydrogels. In this paper, we describe a way to prepare gel film in a capillary tube based on the thermal reversible principle of DNA hydrogel and the principle of capillary action. Because of the slight change in the internal structure of gel, its permeability can be increased by the addition of some specific targets. The capillary behavior is thus changed due to the different permeability of the hydrogel film. The duration time of the target solution flowing through the capillary tube with a specified length is used to quantify this change. With this proposed method, ultra-trace DNA hydrogel (0.01 μL) is sufficient to realize the sensitive detection of cocaine without the aid of other instruments, which has a low detection limit (1.17 nM) and good selectivity.
Databáze: MEDLINE