Effects of Talinum triangulare leaf flavonoid extract on streptozotocin-induced hyperglycemia and associated complications in rats.

Autor: Oluba OM; Food Safety and Toxicology Research Unit Environment and Technology Research Cluster Department of Biological Sciences College of Science and Engineering Landmark University Omu Aran Kwara State Nigeria., Adebiyi FD; Department of Chemical Sciences Joseph Ayo Babalola University Ikeji Arakeji Osun State Nigeria., Dada AA; Department of Chemical Sciences Joseph Ayo Babalola University Ikeji Arakeji Osun State Nigeria., Ajayi AA; Department of Chemical Sciences Joseph Ayo Babalola University Ikeji Arakeji Osun State Nigeria., Adebisi KE; Biochemistry Unit Department of Bioscience and Biotechnology College of Pure and Applied Sciences Kwara State University Ilorin Kwara State Nigeria., Josiah SJ; Department of Biochemistry College of Basic Medical Sciences Igbinedion University Okada Edo State Nigeria., Odutuga AA; Department of Chemical Sciences Joseph Ayo Babalola University Ikeji Arakeji Osun State Nigeria.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2018 Oct 11; Vol. 7 (2), pp. 385-394. Date of Electronic Publication: 2018 Oct 11 (Print Publication: 2019).
DOI: 10.1002/fsn3.765
Abstrakt: Talinum triangulare leaf flavonoid extract (TTFE) was evaluated for its effects on streptozotocin-hyperglycemia and associated complications especially as it relates to dyslipidemia, lipid peroxidation, and renal dysfunction in rats. Two normoglycemic rat groups designated: control (administered distilled water) and control + TTFE (administered 10 mg/kg b.w. TTFE) and two streptozotocin-induced (STZ) diabetic rat groups designated: STZ-control (administered distilled water) and STZ + TTFE (administered 10 mg/kg TTFE). The treatment was given orally once daily for 21 consecutive days. Body weight and insulin concentration showed significant improvement while blood glucose, uric acid, creatinine, and total bilirubin concentrations were significantly reduced in diabetic rats administered TTFE compared to diabetic untreated rats. Furthermore, triglycerides, total cholesterol, LDL-cholesterol, and malondialdehyde concentrations were significantly lowered in diabetic rats administered TTFE compared with diabetic untreated rats. Key enzymes involved in carbohydrate breakdown and cholesterol synthesis, α-amylase and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, respectively, were significantly inhibited in TTFE-treated diabetic rats compared to diabetic control. Results presented in this study suggest that administration of TTFE for 21 days normalized STZ-induced hyperglycemia and its associated dyslipidemia by a mechanism involving inhibition of α-amylase and HMG-CoA reductase activities, respectively, in rats.
Competing Interests: Authors declare that there exists no conflict of interest.
Databáze: MEDLINE
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