Comparative fMRI and MEG localization of cortical sensorimotor function: Bimodal mapping supports motor area reorganization in glioma patients.

Autor: Zimmermann M; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Rössler K; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Kaltenhäuser M; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Grummich P; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Brandner N; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Buchfelder M; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany., Dörfler A; Department of Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany., Kölble K; Department of Neuropathology, University of Erlangen-Nürnberg, Erlangen, Germany., Stadlbauer A; Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany.; Institute of Medical Radiology, University Clinic of St. Pölten, St. Pölten, Austria.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 Mar 07; Vol. 14 (3), pp. e0213371. Date of Electronic Publication: 2019 Mar 07 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0213371
Abstrakt: Introduction: Preoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management. However, space-occupying lesions may lead to functional reorganization or decreased BOLD activity.
Methods: Therefore in 13 patients with cerebral gliomas or brain arterio-venous malformations/ hemangioma fMRI- and MEG-based cortical localizations of motor and somatosensory cortical activation pattern were compared in order to investigate their congruency.
Results: Localization of cortical sensorimotor areas with fMRI and MEG showed good congruency with a mean spatial distance of around 10 mm, with differences depending on the localization method. The smallest mean differences for the centroids were found for MEF with MNE 8 mm and SEF with sLORETA 8 mm. Primary motor area (M1) reorganization was found in 5 of 12 patients in fMRI and confirmed with MEG data. In these 5 patients with M1-reorganization the distance between the border of the fMRI-based cortical M1-localization and the tumor border on T1w MR images varied between 0-4 mm, which was significant (P = 0.025) different to the distance in glioma patients without M1-reorganization (5-26 mm).
Conclusion: Our multimodal preoperative mapping approach combining fMRI and MEG reveals a high degree of spatial congruence and provided high evidence for the presence of motor cortex reorganization.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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