Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis.

Autor:	Meyer CE; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Gao JL; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Cheng JY; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Oberoi MR; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Johnsonbaugh H; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Lepore S; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Kurth F; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Thurston MJ; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Itoh N; UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Patel KR; UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Voskuhl RR; UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., MacKenzie-Graham A; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2020 Mar; Vol. 26 (3), pp. 294-303. Date of Electronic Publication: 2019 Mar 07.
DOI:	10.1177/1352458519830614
Abstrakt:	Background: Gray matter (GM) atrophy in brain is one of the best predictors of long-term disability in multiple sclerosis (MS), and recent findings have revealed that localized GM atrophy is associated with clinical disabilities. GM atrophy associated with each disability mapped to a distinct brain region, revealing a disability-specific atlas (DSA) of GM loss. Objective: To uncover the mechanisms underlying the development of localized GM atrophy. Methods: We used voxel-based morphometry (VBM) to evaluate localized GM atrophy and Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) to evaluate specific pathologies in mice with experimental autoimmune encephalomyelitis (EAE). Results: We observed extensive GM atrophy throughout the cerebral cortex, with additional foci in the thalamus and caudoputamen, in mice with EAE compared to normal controls. Next, we generated pathology-specific atlases (PSAs), voxelwise mappings of the correlation between specific pathologies and localized GM atrophy. Interestingly, axonal damage (end-bulbs and ovoids) in the spinal cord strongly correlated with GM atrophy in the sensorimotor cortex of the brain. Conclusion: The combination of VBM with CLARITY in EAE can localize GM atrophy in brain that is associated with a specific pathology in spinal cord, revealing a PSA of GM loss.
Databáze:	MEDLINE
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