| Autor: |
Elferink H; Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. t.boltje@ru.nl., Rossing E, Huang CH, Lee BW, Cao L, Delsing DJ, Groeneveld A, Boltje TJ |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2019 Mar 20; Vol. 17 (12), pp. 3108-3112. |
| DOI: |
10.1039/c9ob00108e |
| Abstrakt: |
Galactooligosaccharides (GOS) are widely used in the food industry as prebiotics and in very rare cases, can lead to an allergic reaction. Due to the microheterogeneity of GOS it is very difficult to extract pure and well defined oligosaccharides to establish which component is responsible for the observed allergenicity. Herein, we report the chemical synthesis of a suspected allergen 4PX and three closely related oligosaccharides based on a modular approach. The fact that synthesized 4PX and a regioisomer did not cause basophil activation in subjects with confirmed GOS-allergy excludes both tetrasaccharides as key-epitopes in GOS-allergenicity in Singapore. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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