Cortico-Muscular Coherence Is Reduced Acutely Post-stroke and Increases Bilaterally During Motor Recovery: A Pilot Study.

Autor:	Krauth R; Neurocybernetics and Rehabilitation, Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany., Schwertner J; Neurocybernetics and Rehabilitation, Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany., Vogt S; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany., Lindquist S; MZEB, Pfeiffersche Stiftungen, Magdeburg, Germany., Sailer M; MEDIAN Klinik, Neurological Rehabilitation Center, Magdeburg, Germany.; Institute for Neurorehabilitation, Affiliated Institute of the Otto-von-Guericke University, Magdeburg, Germany., Sickert A; MEDIAN Klinik, Neurological Rehabilitation Center, Magdeburg, Germany., Lamprecht J; Institute for Neurorehabilitation, Affiliated Institute of the Otto-von-Guericke University, Magdeburg, Germany., Perdikis S; Defitech Chair in Brain-Machine Interface, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Brain-Computer Interfaces and Neural Engineering Laboratory, School of Computer Science and Electronic Engineering, University of Essex, Colchester, United Kingdom., Corbet T; Defitech Chair in Brain-Machine Interface, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland., Millán JDR; Defitech Chair in Brain-Machine Interface, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland., Hinrichs H; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases, Magdeburg, Germany., Heinze HJ; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases, Magdeburg, Germany., Sweeney-Reed CM; Neurocybernetics and Rehabilitation, Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2019 Feb 20; Vol. 10, pp. 126. Date of Electronic Publication: 2019 Feb 20 (Print Publication: 2019).
DOI:	10.3389/fneur.2019.00126
Abstrakt:	Motor recovery following stroke is believed to necessitate alteration in functional connectivity between cortex and muscle. Cortico-muscular coherence has been proposed as a potential biomarker for post-stroke motor deficits, enabling a quantification of recovery, as well as potentially indicating the regions of cortex involved in recovery of function. We recorded simultaneous EEG and EMG during wrist extension from healthy participants and patients following ischaemic stroke, evaluating function at three time points post-stroke. EEG-EMG coherence increased over time, as wrist mobility recovered clinically, and by the final evaluation, coherence was higher in the patient group than in the healthy controls. Moreover, the cortical distribution differed between the groups, with coherence involving larger and more bilaterally scattered areas of cortex in the patients than in the healthy participants. The findings suggest that EEG-EMG coherence has the potential to serve as a biomarker for motor recovery and to provide information about the cortical regions that should be targeted in rehabilitation therapies based on real-time EEG.
Databáze:	MEDLINE
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