Concerns and Expectations of Risk-Reducing Surgery in Women with Hereditary Breast and Ovarian Cancer Syndrome.

Autor: Modaffari P; Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy. modaffari.paola@gmail.com., Ponzone R; Department of Gynaecological Oncology, Candiolo Cancer Institute, 10060 Candiolo, Italy. riccardo.ponzone@ircc.it., Ferrari A; General Surgery III-Breast Surgery, Department of Surgical Sciences, Fondazione IRCCS Policlinico S. Matteo Foundation, University of Pavia, 27100 Pavia, Italy. A.Ferrari@smatteo.pv.it., Cipullo I; Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy. isabella.cipullo@edu.unito.it., Liberale V; Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy. viola.liberale@gmail.com., D'Alonzo M; Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy. martadalonzo@libero.it., Maggiorotto F; Department of Gynaecological Oncology, Candiolo Cancer Institute, 10060 Candiolo, Italy. furio.maggiorotto@ircc.it., Biglia N; Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy. nicoletta.biglia@unito.it.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2019 Mar 05; Vol. 8 (3). Date of Electronic Publication: 2019 Mar 05.
DOI: 10.3390/jcm8030313
Abstrakt: Hereditary Breast and Ovarian Cancer syndrome (HBOC) carriers face complex decisions, which might affect their fertility and body image. Using an anonymous 40-items questionnaire we evaluated the expectations and concerns about Risk-Reducing Surgery (RRS) in 204 carriers. Participants are well-informed about the options to manage cancer risk, and women with previous cancer are more concerned with screening failure. Satisfaction with RR Mastectomy is high, even if many carriers are unsatisfied with reconstructed breast feel and nipple-areola complex tactile sensation and those with previous breast cancer report a change in their sexual habits. The decrease of libido and vaginal dryness are the most complained symptoms after RR Salpingo-Oophorectomy. Nevertheless, most carriers would choose RRS again, due to cancer risk or screening-related stress reduction. Women who deferred RRS are more afraid of menopausal symptoms and cancer risk than those who had undergone or declined surgery. Women who declined RRS feel well-informed and trust screening procedures. In conclusion, HBOC carriers consider themselves well-informed and able to choose the best option for their condition, would choose RRS again because of cancer risk and screening-related stress reduction, and those who delay RRS face a higher preoperative level of concern and need support.
Databáze: MEDLINE