Anticonvulsant, sedative, anxiolytic and antidepressant activities of the essential oil of Annona vepretorum in mice: Involvement of GABAergic and serotonergic systems.

Autor: Diniz TC; Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900, Feira de Santana, Bahia, Brazil., de Oliveira Júnior RG; Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56304-205, Petrolina, Pernambuco, Brazil., Miranda Bezerra Medeiros MA; Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900, Feira de Santana, Bahia, Brazil., Gama E Silva M; Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56304-205, Petrolina, Pernambuco, Brazil., de Andrade Teles RB; Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900, Feira de Santana, Bahia, Brazil., Dos Passos Menezes P; Department of Pharmacy, Federal University of Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil., de Sousa BMH; Department of Pharmacy, Federal University of Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil., Abrahão Frank L; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., de Souza Araújo AA; Department of Pharmacy, Federal University of Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil., Russo Serafini M; Department of Pharmacy, Federal University of Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil., Stanisçuaski Guterres S; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Pereira Nunes CE; Institute of Biology, Department of Plant Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Salvador MJ; Institute of Biology, Department of Plant Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., da Silva Almeida JRG; Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900, Feira de Santana, Bahia, Brazil; Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56304-205, Petrolina, Pernambuco, Brazil. Electronic address: jackson.guedes@univasf.edu.br.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Mar; Vol. 111, pp. 1074-1087. Date of Electronic Publication: 2019 Jan 11.
DOI: 10.1016/j.biopha.2018.12.114
Abstrakt: Annona vepretorum is an endemic species of the Caatinga biome, known in Northeastern Brazil as "araticum" and/or "pinha da Caatinga". In the present study it was evaluated the neuropharmacological potential of the essential oil obtained from the leaves of Annona vepretorum, as well as of the inclusion complexes of oil obtained with cyclodextrin. Thus, were used neuropharmacological tests already consolidated in the literature like open-field, elevated plus maze, rota-rod, tail suspension test, thiopental-induced sleep test, among others. The acute treatment of essential oil (EO) has anxiolytic, sedative, antiepileptic and antidepressant effects. The anxiolytic and anticonvulsant effects seems to be related to the GABAergic system, probably in the receptor subtypes that mediate the effects of the benzodiazepines, to generate anxiolytic activity. The sedative effect seems to be involved with other signaling pathways. The antidepressant effect of EO seems to be related to its action on serotonergic receptors. It was verified that some behavioral parameters were improved with the oil complexed with β-cyclodextrin, but this effect was not uniform for all the doses and tests used. Further studies are needed in order to use other options for drug delivery systems. Thus, the essential oil of Annona vepretorum is a promising agent with neurobiological activity and a potential target for drug discovery, since the natural products such as medicinal plants have been a source of new therapeutic proposals.
(Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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