Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes.

Autor: Lyra E Silva NM; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Lam MP; Department of Psychiatry, Queen's University, Kingston, ON, Canada., Soares CN; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.; Department of Psychiatry, Queen's University, Kingston, ON, Canada., Munoz DP; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Milev R; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.; Department of Psychiatry, Queen's University, Kingston, ON, Canada., De Felice FG; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.; Department of Psychiatry, Queen's University, Kingston, ON, Canada.; Institute of Medical Biochemistry Leopoldo De Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Frontiers in psychiatry [Front Psychiatry] 2019 Feb 14; Vol. 10, pp. 57. Date of Electronic Publication: 2019 Feb 14 (Print Publication: 2019).
DOI: 10.3389/fpsyt.2019.00057
Abstrakt: Neuropsychiatric disorders and type 2 diabetes (T2D) are major public health concerns proposed to be intimately connected. T2D is associated with increased risk of dementia, neuropsychiatric and mood disorders. Evidences of the involvement of insulin signaling on brain mechanisms related to depression indicate that insulin resistance, a hallmark of type 2 diabetes, could develop in the brains of depressive patients. In this article, we briefly review possible molecular mechanisms associating defective brain insulin signaling with reward system, neurogenesis, synaptic plasticity and hypothalamic-pituitary-adrenal (HPA) stress axis in depression. We further discuss the involvement of tumor necrosis factor α (TNFα) promoting defective insulin signaling and depressive-like behavior in rodent models. Finally, due to the high resistant rate of anti-depressants, novel insights into the link between insulin resistance and depression may advance the development of alternative treatments for this disease.
Databáze: MEDLINE