Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance.

Autor:	Brock CK; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wallin ST; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Ruiz OE; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Samms KM; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Mandal A; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Sumner EA; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Eisenhoffer GT; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. gteisenhoffer@mdanderson.org.; Genetics and Epigenetics Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. gteisenhoffer@mdanderson.org.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2019 Mar 05; Vol. 10 (1), pp. 1044. Date of Electronic Publication: 2019 Mar 05.
DOI:	10.1038/s41467-019-09010-6
Abstrakt:	Epithelial tissues require the removal and replacement of damaged cells to sustain a functional barrier. Dying cells provide instructive cues that can influence surrounding cells to proliferate, but how these signals are transmitted to their healthy neighbors to control cellular behaviors during tissue homeostasis remains poorly understood. Here we show that dying stem cells facilitate communication with adjacent stem cells by caspase-dependent production of Wnt8a-containing apoptotic bodies to drive cellular turnover in living epithelia. Basal stem cells engulf apoptotic bodies, activate Wnt signaling, and are stimulated to divide to maintain tissue-wide cell numbers. Inhibition of either cell death or Wnt signaling eliminated the apoptosis-induced cell division, while overexpression of Wnt8a signaling combined with induced cell death led to an expansion of the stem cell population. We conclude that ingestion of apoptotic bodies represents a regulatory mechanism linking death and division to maintain overall stem cell numbers and epithelial tissue homeostasis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu